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Taste Making Resins for Norfloxacin
Polacrillin Potassium is derived from crosslinked
Polymer of Polycarboxylic Acids & has a K+ ionic form. Polacrillin
Potassium is a very high purity Polymer finding use in pharmaceutical
formulations as a Tablet Disintegrant in the oral dosage formulations.
Taste Masking Agent - 104
Taste Masking Agent - 104 is derived from
crosslinked polymer of Methacrylic acid. Taste Masking Agent - 104 has
carboxylic acid functionally which is enables its use as a TASTE MASKING
AGENT, while the cross linked porous nature makes its suitable as a SUSTAIN
RELEASE AGENT.
Specifications
The Physical & Chemical properties are as under
:
 |
| Physical
Properties |
| Appearance |
White to off white
free flowing powder. |
| Solubility |
Insoluble in water &
common solvents |
| Moisture Content |
10% max. |
| Particle Size |
1% max. retained on
100 BSS &
70% min. passing through 200 BSS |
| Chemical
Properties |
| Polymeric Functional
Group |
Carboxylic Acid |
| Sodium Content |
0.2% max. |
| Iron Content as Fe |
100 ppm max. |
| Heavy Metals as Pb |
10 ppm max. |
| Arsenic Content as As |
3 ppm max. |
|
|
Applications
Taste Masking Agent : A drug polymer adduct
can be synthesized due to the ionic bonding between the bitter drug and the
polymer thus masking the objectionable bitter taste of the drug. Since the
polymer drug adduct so formed is tasteless in the mouth, but it dissociates
in the acidic pH of the stomach, the bio availability of the drug is not
effected.
Examples : Norfloxacin, Ofloxacin
Sustain Release of Nicotine : The crosslinked porous polymer
facilitates sustain release of nicotine.
Toxicity
Taste Masking Agent - 104 is high molecular weight
polymer so can't be absorbed by body tissued & is safe for human
consumption. It has no any physiological action at recommended dosage &
it is non-toxic.
Storage
Store in tightly container. Keep away from moisture.
If moisture is absorbed, dry at 900C to 1000C to remove moisture content
below 10%.
Packing
5 kg, 20 kg, in Corrugated Box.
Note : Application notes and MSDS sheet can be made available on
request
Taste Masking Rosin - 134
Taste Masking Rosin - 134 is derived from
crosslinked polymer of acrylic acid and has a K + ionic form. Taste Masking
Rosin - 134 is a very high purity polymer finding use in pharmaceutical
formulations for TASTE MASING of certain drugs, particularly B-lactum
antibiotics.
Specifications
The Physical & Chemical properties are as under
:
|
| Physical
Properties |
| Appearance |
White to off white
free flowing powder. |
| Solubility |
Insoluble in water &
common solvents |
| Moisture Content |
10% max. |
| Particle Size |
1% max. retained on
100 BSS &
70% min. passing through 200 BSS |
| Chemical
Properties |
| Polymeric Functional
Group |
Carboxylic Acid |
| Potassium content |
Potassium content
20.6 to 25.1% |
| Sodium Content |
0.2% max. |
| Iron Content as Fe |
100 ppm max. |
| Heavy Metals as Pb |
10 ppm max. |
| Arsenic Content as As |
3 ppm max. |
|
|
Applications
Taste Masking Agent : Taste Masking Rosin -
134 forms complex with drug & mask it's bitter taste. This complex
formed does not dissociate in saliva pH but, dissociate in acidic pH of
stomach. Thus this complex is tasteless without affecting its bio
availability. This technique helps to formulate palatable & chewable
tablets, dispersible tablet & suspensions of bitter taste drugs.
Examples : Chloroquine Phosphate, Ciprofloxacin HCL, Chloroquine
Sulphate, Dextromethorphan Hydrobromide, Metoclopramide Hydrochloride.
Toxicity
Taste Masking Rosin - 134 is high molecular weight
polymer so can't be absorbed by body tissues & is safe for human
consumption. It has no any physiological action at recommended dosage &
it is non-toxic.
Storage
Store in tightly closed container. Keep away from
moisture. If moisture is absorbed dry at 900C to 1000C to remove moisture
content below 10%.
Packing
5 kg, 20 kg, in Corrugated Box.
